Swiss-PO

double-click on a variant will focus on the 3D structure viewer (if the residue is present in the selected 3D structure) and the sequence alignment of homologenes accordingly.

Controls:

1. Mouse left-button + drag: rotate the system
2. Mouse right-button + drag: translate the system
3. Mouse wheel up and down: zoom and unzoom
4. Hitting "i" key: roll the system. Hitting "i" again stop the rolling.
5. Hitting "k" key: rock the system. Hitting "k" again stop the rocking.

A double-click on a residue will center the view on this residue, while displaying it in ball and stick and the close neighbours in licorice.
At the same time, if the double-click has been made on a residue in the main chain, the variant table, and the homologous sequence alignment, will focus on the same residue.

A single-click on a residue will center the system on it, without changing the selection.

Hovering the mouse pointer on an atom will display the atom name, as well as the residue name and number above the 3D viewer.

It is possible to display several types of molecular interactions between the selected residue and its environment using the different options available below the 3D viewer.

Full screen viewing and a summary of the 3D structure information can be obtained by clicking on the and icons, respectively.

A single-click on the residue number or a double-click on a residue letter in the sequence alignment will center the 3D structure and the table of variants accordingly.
Residue numbers are displayed above the sequence alignment for the human protein, if they are present in the selected 3D structure.

A multiple sequence alignment of protein sequences of the same subfamily of the selected protein.
The sequences list and family attribution are based on UniProt database. All sequences retrieved from UniProt data.

A multiple sequence alignment of protein sequences of the same family of the selected protein.
The sequences list and family attribution are based on UniProt database. All sequences retrieved from UniProt data.

A multiple sequence alignment of orthologous sequences of a protein against human's one.
All sequences are retrieved from UniProt database.